Physiology 2015

Motorpoint Arena Cardiff, UK
6 to 8 July

Key Dates

15 June

Online registration closes

Further key dates

Gaseous regulation of Ca2+ homeostasis; for better or worse?

Wednesday 8 July 9.00 - 11.00
Main Arena Plenary Lecture Theatre, Ground Floor

Organiser: Mark Dallas, University of Reading, UK
Cardiac & Respiratory Physiology

Calcium homeostasis is central to a host of physiological processes and dysregulation of intracellular Ca2+ levels is implicated in a variety of disease states. Recent research has shown that toxic gases, such as carbon monoxide and hydrogen sulfide, are important signalling molecules paramount to both physiology and pathology. There are a growing number of reports highlighting the effects of the gasotransmitters on an array of molecular targets that influence the intracellular levels of Ca2+. This symposium therefore will inform two distinct scientific communities as to the fundamental use of gasotransmitters as potential therapeutic options.

For publication in The Journal of Physiology

Speaker panel includes:

9.00 - 9.30
Actions and interactions of H2S with NO in the cardiovascular system
Andreas Papapetropoulos, University of Athens, Greece

9.30 - 9.45
Carbon monoxide and mitochondria: modulation of cell metabolism and cell death
Helena Vieira, Universidade Nova de Lisboa, Portugal

9.45 - 10.15
Mitochondria-targeted hydrogen sulfide: A novel therapeutic opportunity?
Matt Whiteman, University of Exeter, UK

10.15 - 10.30
Physiological concentrations of hydrogen sulfide selectively inhibit Cav3.2 T-type Ca2+ channels
Jacobo Elies, University of Leeds, UK

10.30 - 11.00
Hydrogen sulfide, EDHF, and calcium
Rui Wang, Lakehead University, Canada